2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N11677
    7-Hydroxy-TSU-68
    7-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68.
    7-Hydroxy-TSU-68
  • HY-113629
    2-Keto-D-Glucose
    2-Keto-D-Glucose (D-Glucosone) is a key intermediate in a secondary metabolic pathway leading to the antibiotic Cortalcerone. 2-Keto-D-Glucose is also an intermediate in the conversion of D-glucose into D-fructose. 2-Keto-D-Glucose is found in various natural sources, including fungi, algae, and shellfish.
    2-Keto-D-Glucose
  • HY-143984S
    Minodronic acid impurity 2-d4
    Minodronic acid impurity 2-d4 is the deuterium labeled Minodronic acid impurity 2[1].
    Minodronic acid impurity 2-d<sub>4</sub>
  • HY-144242S
    Voriconazole EP impurity D-d3
    Voriconazole EP impurity D-d3 is the deuterium labeled Voriconazole EP impurity D[1].
    Voriconazole EP impurity D-d<sub>3</sub>
  • HY-12784AS1
    Cycloguanil-d6 hydrochloride
    Cycloguanil-d6 hydrochloride is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil-d<sub>6</sub> hydrochloride
  • HY-133694S
    2-Aminoflubendazole-13C6
    2-Aminoflubendazole-13C6 is the 13C6 labeled 2-Aminoflubendazole. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
    2-Aminoflubendazole-<sup>13</sup>C<sub>6</sub>
  • HY-I0678S
    Regorafénib N-oxyde-d3(M2)
    Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/Flt-1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].
    Regorafénib N-oxyde-d<sub>3</sub>(M2)
  • HY-143985S
    Maytansinoid DM4 impurity 5-d6
    Maytansinoid DM4 impurity 5-d6 is the deuterium labeled Maytansinoid DM4 impurity 5[1].
    Maytansinoid DM4 impurity 5-d<sub>6</sub>
  • HY-B1415R
    Clofibric acid (Standard)
    Clofibric acid (Standard) is the analytical standard of Clofibric acid. This product is intended for research and analytical applications. Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide.
    Clofibric acid (Standard)
  • HY-144221S
    Tiotropium bromide EP impurity A-d6
    Tiotropium bromide EP impurity A-d6 is the deuterium labeled Tiotropium bromide EP impurity A[1].
    Tiotropium bromide EP impurity A-d<sub>6</sub>
  • HY-135580A
    Raloxifene Bismethyl Ether hydrochloride
    Raloxifene Bismethyl Ether hydrochloride is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent.
    Raloxifene Bismethyl Ether hydrochloride
  • HY-145482
    W36017
    W3601 is the impurity of Lidocaine. W3601 exhibits nerve blocking activity with the pKa of 7.4.
    W36017
  • HY-143988S
    Nefazodone impurity 3-d6
    Nefazodone impurity 3-d6 is the deuterium labeled Nefazodone impurity 3[1].
    Nefazodone impurity 3-d<sub>6</sub>
  • HY-135389S
    Desmethyl Levofloxacin-d8 hydrochloride
    Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
    Desmethyl Levofloxacin-d<sub>8</sub> hydrochloride
  • HY-N10382
    20,26-Dihydroxyecdysone
    20,26-Dihydroxyecdysone is a predominant ecdysteroid metabolite.
    20,26-Dihydroxyecdysone
  • HY-136457
    2-NP-AHD
    2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents.
    2-NP-AHD
  • HY-133110
    Afatinib N-Oxide
    Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor.
    Afatinib N-Oxide
  • HY-129099
    N-Desmethyltamoxifen
    N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
    N-Desmethyltamoxifen
  • HY-143938S
    Cyclobenzaprine impurity 2-d3 hydrochloride
    Cyclobenzaprine impurity 2-d3 (hydrochloride) is the deuterium labeled Cyclobenzaprine impurity 2 hydrochloride[1].
    Cyclobenzaprine impurity 2-d<sub>3</sub> hydrochloride
  • HY-100635
    Diacetolol
    Diacetolol is an active metabolite of the beta-adrenoceptor blocking agent Acebutolol (HY-17497).
    Diacetolol
Cat. No. Product Name / Synonyms Application Reactivity